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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S249

and hope, while it correlates negatively with Depression and Anx-

iety.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.502

EW385

Detection of the relationship between

clinical features consist of

psychopathy levels and MTHFR

mutation among subjects with

antisocial personality disorder

C. Basoglu

1 ,

, G. Ozgur Meral

2

, A. Ates

3

, A. Algul

3

,

T. Muftuoglu

4

, R. Tutuncu

3

, H. Balibey

2

, O. Ipcioglu

4

1

Gata Haydarpasa Training Hospital, Psychiatry Service, Istanbul,

Turkey

2

Turkey

3

Psychiatry Service, Turkey

4

Biochemistry Service, Turkey

Corresponding author.

Objective

The aim of this study is to explore the presence

of MTHFR mutation and its correlation with psychometric tests

among subjects with antisocial personality disorder.

Methods

One hundred and eight male subjects meeting DSM-

IV-TR diagnostic criteria for ASPD who admitted to outpatient

unit of Department of Psychiatry at GATA Haydarpasa Training

Hospital were included in the study. The patients and control sub-

jects were assessed by Hare Psychopathy Checklist-Revised, Barratt

Impulsiveness Scale (BIS-11), Resilience Scale for adults and Tem-

perament and Character Inventory. Real time PCR method is used

in order to identify MTHFR mutation among subjects.

Results

In this study; all of the groups showed more “non-

planning, lack of control impulsiveness” than other kinds. Also

groupsweren’t resilient in “perception of future”, “structured style”

and “social competence” subgroups, groups with heterozygous

and homozygous mutations were and group without mutation

wasn’t resilient in “perception of self” subgroup, group with

heterozygous mutation +without mutation were and group with

homozygous mutation was not resilient in “family cohesion” and

“social resources” subgroups. We found high novelty seeking,

harm avoidance, cooperativeness, self-directedness points and low

reward dependence, self-transcendence points. On the other hand,

it’s identified that the impulsiveness among subjects with ASPD

was non-planning type.

Conclusion

In our study; there was not a significant correlation

identified between the MTHFR enzyme mutation and ASPD. We

thought that limitation of our study sample and not to measure

MTHFR enzyme activity may play role to get these results. Addi-

tional work is needed to examine in large groups and with MTHFR

enzyme activity measure.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.503

EW386

Family skills training in dialectical

behaviour therapy: The experience of

the significant others

S. Ekdahl

1 ,

, E. Idvall

1

, K.I. Perseius

2

1

Malmö University, Faculty of Health & Society, The Department of

Care Science, Malmö, Sweden

2

Red Cross University College, Department of psychiatric nursing,

Stockholm, Sweden

Corresponding author.

Introduction

Borderline personality disorder (BPD) is a severe

psychiatric health problem with reputation of being difficult to

deal with and to treat. Significant others (SOs) of patients with

BPD show higher levels of psychological distress compared with

the general population. Strengthening the coping strategies of SOs

plays an important role in the recovery of the patient. Support and

education for SOs is important, both for SOs themselves and for the

patients recovery.

Objectives

Research around support and education for SOs is of

great importance not only for SOs and patients, but also for psychi-

atric staff, in order to offer help and support, for the whole family.

Aim

The aim was to describe significant others’ experiences of

dialectical behaviour therapy-family skills training (DBT-FST), their

life situation before and after DBT-FST, and measurement of their

levels of anxiety and depressive symptoms.

Methods

The study had a descriptive mixed method design. Data

were collected with free text questionnaires (

n

= 44), group inter-

views (

n

= 53) and theHAD scale (

n

= 52) and analysed by qualitative

content analysis and descriptive and inferential statistics.

Results

The results show that life before DBT-FST was a struggle.

DBT-FST gave hope for the future and provided strategies, helpful

in daily life. For the subgroup without symptoms of anxiety and

depression before DBT-FST, anxiety increased significantly. For the

subgroup with symptoms of anxiety and depression the symptoms

decreased significantly. This indicates, despite increased anxiety

for one group, that DBT-FST is a beneficial intervention and most

beneficial for those with the highest anxiety and depressive symp-

toms.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.504

EW387

The purpose of this research was

standardizing the questionnaire of

personality disorder Cluster A

N. Farrokhi Namini

Islamic Azad University Roudehen Branch, Psychology, Tehran, Iran

Introduction

As more or less stable personality traits of the per-

son, temperament, intellect and body that makes an individual

unique compatibility with the environment.

Objective

The purpose of this research was standardizing the

questionnaire of personality disorder Gluster A. On the basis of

realizing criterion standard, DSM-5.

Method

A total of 1303 people from universities of Tehran and

Alborz provinces (753 females and 550 males) were examined by

using the randomized samplingmethod. The questions of the ques-

tionnaire were conformed Dr. Shahram Vaziri on the basis of Iran s

population and culture. Then the reliability was tested and accom-

plished simultaneously Millon (MCMI-III) questionnaire.

Result

After computing the correlation scales of Millon test with

each of the questions, 20 questions that showed the highest cor-

relation and diagnosis coefficient were chosen and scored again in

next stage.

Conclusions

Investigating the psychometric component of three

scales (Paranoid 60%, Schizoid 66%, Schizotypal 59%) shows that

they are reliable and defensibly valid. It can be said that questions

related to all three measures paranoid, schizoid and schizotypal of

acceptable psychometric properties and reliability are desirable.

Keywords

Personality disorder; Cluster A; Paranoid; Schizoid;

Schizotypal

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.505