European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S249
and hope, while it correlates negatively with Depression and Anx-
iety.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW385
Detection of the relationship between
clinical features consist of
psychopathy levels and MTHFR
mutation among subjects with
antisocial personality disorder
C. Basoglu ∗, G. Ozgur Meral , A. Ates , A. Algul ,
T. Muftuoglu , R. Tutuncu , H. Balibey , O. Ipcioglu
1 Gata Haydarpasa Training Hospital, Psychiatry Service, Istanbul,
Turkey
2 Turkey
3 Psychiatry Service, Turkey
4 Biochemistry Service, Turkey
∗ Corresponding author.
Objective The aim of this study is to explore the presence
of MTHFR mutation and its correlation with psychometric tests
among subjects with antisocial personality disorder.
Methods One hundred and eight male subjects meeting DSM-
IV-TR diagnostic criteria for ASPD who admitted to outpatient
unit of Department of Psychiatry at GATA Haydarpasa Training
Hospital were included in the study. The patients and control sub-
jects were assessed by Hare Psychopathy Checklist-Revised, Barratt
Impulsiveness Scale (BIS-11), Resilience Scale for adults and Tem-
perament and Character Inventory. Real time PCR method is used
in order to identify MTHFR mutation among subjects.
Results In this study; all of the groups showed more “non-
planning, lack of control impulsiveness” than other kinds. Also
groupsweren’t resilient in “perception of future”, “structured style”
and “social competence” subgroups, groups with heterozygous
and homozygous mutations were and group without mutation
wasn’t resilient in “perception of self” subgroup, group with
heterozygous mutation +without mutation were and group with
homozygous mutation was not resilient in “family cohesion” and
“social resources” subgroups. We found high novelty seeking,
harm avoidance, cooperativeness, self-directedness points and low
reward dependence, self-transcendence points. On the other hand,
it’s identified that the impulsiveness among subjects with ASPD
was non-planning type.
Conclusion In our study; there was not a significant correlation
identified between the MTHFR enzyme mutation and ASPD. We
thought that limitation of our study sample and not to measure
MTHFR enzyme activity may play role to get these results. Addi-
tional work is needed to examine in large groups and with MTHFR
enzyme activity measure.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW386
Family skills training in dialectical
behaviour therapy: The experience of
the significant others
S. Ekdahl ∗, E. Idvall , K.I. Perseius
1 Malmö University, Faculty of Health & Society, The Department of
Care Science, Malmö, Sweden
2 Red Cross University College, Department of psychiatric nursing,
Stockholm, Sweden
∗ Corresponding author.
Introduction Borderline personality disorder (BPD) is a severe
psychiatric health problem with reputation of being difficult to
deal with and to treat. Significant others (SOs) of patients with
BPD show higher levels of psychological distress compared with
the general population. Strengthening the coping strategies of SOs
plays an important role in the recovery of the patient. Support and
education for SOs is important, both for SOs themselves and for the
patients recovery.
Objectives Research around support and education for SOs is of
great importance not only for SOs and patients, but also for psychi-
atric staff, in order to offer help and support, for the whole family.
Aim The aim was to describe significant others’ experiences of
dialectical behaviour therapy-family skills training (DBT-FST), their
life situation before and after DBT-FST, and measurement of their
levels of anxiety and depressive symptoms.
Methods The study had a descriptive mixed method design. Data
were collected with free text questionnaires (n = 44), group inter-
views (n = 53) and theHAD scale (n = 52) and analysed by qualitative
content analysis and descriptive and inferential statistics.
Results The results show that life before DBT-FST was a struggle.
DBT-FST gave hope for the future and provided strategies, helpful
in daily life. For the subgroup without symptoms of anxiety and
depression before DBT-FST, anxiety increased significantly. For the
subgroup with symptoms of anxiety and depression the symptoms
decreased significantly. This indicates, despite increased anxiety
for one group, that DBT-FST is a beneficial intervention and most
beneficial for those with the highest anxiety and depressive symp-
toms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW387
The purpose of this research was
standardizing the questionnaire of
personality disorder Cluster A
N. Farrokhi Namini
Islamic Azad University Roudehen Branch, Psychology, Tehran, Iran
Introduction As more or less stable personality traits of the per-
son, temperament, intellect and body that makes an individual
unique compatibility with the environment.
Objective The purpose of this research was standardizing the
questionnaire of personality disorder Gluster A. On the basis of
realizing criterion standard, DSM-5.
Method A total of 1303 people from universities of Tehran and
Alborz provinces (753 females and 550 males) were examined by
using the randomized samplingmethod. The questions of the ques-
tionnaire were conformed Dr. Shahram Vaziri on the basis of Iran s
population and culture. Then the reliability was tested and accom-
plished simultaneously Millon (MCMI-III) questionnaire.
Result After computing the correlation scales of Millon test with
each of the questions, 20 questions that showed the highest cor-
relation and diagnosis coefficient were chosen and scored again in
next stage.
Conclusions Investigating the psychometric component of three
scales (Paranoid 60%, Schizoid 66%, Schizotypal 59%) shows that
they are reliable and defensibly valid. It can be said that questions
related to all three measures paranoid, schizoid and schizotypal of
acceptable psychometric properties and reliability are desirable.
Keywords Personality disorder; Cluster A; Paranoid; Schizoid;
Schizotypal
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.