European Psychiatry - Volume 33 - March 2016

662 / 812

S658 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV966
Modulation of the nuclear factor
(erythroid 2-derived)-like 2 pathway
by antidepressants in rats
D. Martín Hernández ∗ . Bris , K.S. MacDowell , A. Sayd ,
D. Azpiazu , M.T. Alba , G. Torres , B. García-Bueno ,
J.L.M. Madrigal , J.C. Leza , J.R. Caso
Complutense university of Madrid, school of medicine, CIBERSAM,
pharmacology, Madrid, Spain
∗ Corresponding author.
Introduction Patients with major depression who are otherwise
medically healthy have activated inflammatory pathways. It has
been described that depression is not only escorted by inflamma-
tion but also by induction of multiple oxidative/nitrosative stress
pathways. Nevertheless, there are finely regulated mechanisms
involved in preserving cells fromdamage, such as the nuclear factor
Nrf2.
Aims To explore in a depression-like model the Nrf2 pathway in
the prefrontal cortex (PFC) and the hippocampus of rats and to ana-
lyze which classic antidepressants affect the antioxidant activity of
the Nrf2 pathway.
Methods Male Wistar rats were exposed to chronic mild stress
(CMS) and some of them were treated with desipramine, escitalo-
pram or duloxetine. We studied the expression in the PFC and
hippocampus of upstream and downstream elements of the Nrf2
pathway and the oxidative damage induced by the CMS.
Results After exposure to a CMS protocol, in the PFC, there
is an inhibition of upstream and downstream elements of the
Nrf2 pathway. Moreover, antidepressant treatments, particularly
desipramine and duloxetine, are able to recover some of these
elements and to reduce the oxidative damage induced by the
depressionmodel. In the hippocampus however, Nrf2 pathways are
not that affected and antidepressants do not have many actions.
Conclusions Nrf2 pathway is differentially regulated by antide-
pressants in the PFC and hippocampus. The Nrf2 pathway is
involved in the oxidative/nitrosative damage detected in the PFC
after CMS exposure. However, it seems that Nrf2 is not very
involved in the effects caused by the CMS in the hippocampus.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Psychopathology
EV967
Auditory hallucinations in a deaf
patient? – A clinical report
M.A. Aleixo ∗ . Moreira Sobreira liveira
L. Carvalhão Gil
1 Centro hospitalar psiquiátrico de Lisboa, Ward 1, first psychotic
episode unit, Lisboa, Portugal
2 Centro hospitalar psiquiátrico de Lisboa, Ward 6, schizophrenia and
schizoaffective disorders unit, Lisboa, Portugal
3 Centro hospitalar psiquiátrico de Lisboa, Ward 2, neuropsychiatry
and dementia unit, Lisboa, Portugal
∗ Corresponding author.
Introduction According to some studies, deaf psychiatric inpa-
tients have prevalence rates of psychotic disorders ranging from
20 to 54%. There are descriptions of the paradoxical finding that
prelingually deaf patients with psychosis may hear voices.
Objectives To present a case report and conduct a database
review in order to understand if deaf patients with psychosis can
have auditory hallucinations.
Aims The authors’ aim is to describe a case, highlight the clinical
and scientific relevance of auditory hallucinations in deaf patients
and the difficulties and limitations of this process.
Methods A Pubmed database search using as keywords “auditory
hallucinations”, “deaf” and “deafness” and retrieved papers were
selected according to their relevance.
Results The authors report a case of a 47-year-old female patient
apparently suffering from congenital deafness. The patient had no
previous psychiatric history until 4 months prior to her admission
at our institution, when she started having psychotic symptoms.
The patient was admitted into a Neurology ward but because no
neurological sign was found psychiatric liaison consultation was
requested. Four months later, she had the same symptoms, describ-
ing a voice that said to “shut up” and was admitted to a psychiatric
hospital. After medication, the symptoms relapsed and now she is
followed in an outpatient setting.
The presence and nature of auditory hallucinations in deaf patients
is not fully elucidated and there are methodological problems in
the investigation of this subject.
Conclusions Current evidence is still inconclusive and the fact
that prelingually deaf patient hear voices needs further research.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV968
“Yo Soy La Desintegración”:
Helplessness and sublimation through
Frida Kahlo’s history
J. Becker
Coimbra, Portugal
Considering the relevance of studying the pathologies of emptiness
for contemporaneous clinic, this work approaches the correlation
between helplessness and sublimation concepts. Helplessness is
considered a new theory, developed by David Maldavsky that uses
the term desvalimiento to define a clinical condition described by
the feeling of emptiness. To understand this concept, it is neces-
sary to return to a primitive period, when the baby is beginning
to qualify his affections. Thus, using historical construction, we
start at Freud’s works (focusing in the primitive period and the
affections qualification), explore the “good-enoughmother” impor-
tance, from Winnicott, and reaching the helplessness from the
present-days Maldavsky’s studies. The Frida Kahlo’s history illus-
trates this work as much because of her toxic current as because
of her talent to sublimate. The maternal failure, the toxic rela-
tionships, the trauma’s imposition, the abuse of alcohol and drugs
and the viscosity denounce her helplessness. Nevertheless, the art
expresses her fight for life. The Frida Kahlo’s works represent her
suffering, but they also are her attempts to understand her feel-
ings and to reframe her traumatic events. Therefore, we introduce
the sublimation as an alternative to the helplessness. Although
helplessness is the lack of the symbolic life, we present the art
as an opportunity to confront experiences, which can allow the
representation of the traumas and the qualification of affections.
Through the sublimation, Frida Kahlo recreated her inner world
and returned to life.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.