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S658

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1950

EV966

Modulation of the nuclear factor

(erythroid 2-derived)-like 2 pathway

by antidepressants in rats

D. Martín Hernández

, Á.G

. Bris , K.S. MacDowell , A. Sayd ,

D. Azpiazu , M.T. Alba , G. Torres , B. García-Bueno ,

J.L.M. Madrigal , J.C. Leza , J.R. Caso

Complutense university of Madrid, school of medicine, CIBERSAM,

pharmacology, Madrid, Spain

Corresponding author.

Introduction

Patients with major depression who are otherwise

medically healthy have activated inflammatory pathways. It has

been described that depression is not only escorted by inflamma-

tion but also by induction of multiple oxidative/nitrosative stress

pathways. Nevertheless, there are finely regulated mechanisms

involved in preserving cells fromdamage, such as the nuclear factor

Nrf2.

Aims

To explore in a depression-like model the Nrf2 pathway in

the prefrontal cortex (PFC) and the hippocampus of rats and to ana-

lyze which classic antidepressants affect the antioxidant activity of

the Nrf2 pathway.

Methods

Male Wistar rats were exposed to chronic mild stress

(CMS) and some of them were treated with desipramine, escitalo-

pram or duloxetine. We studied the expression in the PFC and

hippocampus of upstream and downstream elements of the Nrf2

pathway and the oxidative damage induced by the CMS.

Results

After exposure to a CMS protocol, in the PFC, there

is an inhibition of upstream and downstream elements of the

Nrf2 pathway. Moreover, antidepressant treatments, particularly

desipramine and duloxetine, are able to recover some of these

elements and to reduce the oxidative damage induced by the

depressionmodel. In the hippocampus however, Nrf2 pathways are

not that affected and antidepressants do not have many actions.

Conclusions

Nrf2 pathway is differentially regulated by antide-

pressants in the PFC and hippocampus. The Nrf2 pathway is

involved in the oxidative/nitrosative damage detected in the PFC

after CMS exposure. However, it seems that Nrf2 is not very

involved in the effects caused by the CMS in the hippocampus.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1951

Psychopathology

EV967

Auditory hallucinations in a deaf

patient? – A clinical report

M.A. Aleixo

1 ,

, C .A

. Moreira

2 , G.

Sobreira

1 , J. O

liveira

3 ,

L. Carvalhão Gil

2

1

Centro hospitalar psiquiátrico de Lisboa, Ward 1, first psychotic

episode unit, Lisboa, Portugal

2

Centro hospitalar psiquiátrico de Lisboa, Ward 6, schizophrenia and

schizoaffective disorders unit, Lisboa, Portugal

3

Centro hospitalar psiquiátrico de Lisboa, Ward 2, neuropsychiatry

and dementia unit, Lisboa, Portugal

Corresponding author.

Introduction

According to some studies, deaf psychiatric inpa-

tients have prevalence rates of psychotic disorders ranging from

20 to 54%. There are descriptions of the paradoxical finding that

prelingually deaf patients with psychosis may hear voices.

Objectives

To present a case report and conduct a database

review in order to understand if deaf patients with psychosis can

have auditory hallucinations.

Aims

The authors’ aim is to describe a case, highlight the clinical

and scientific relevance of auditory hallucinations in deaf patients

and the difficulties and limitations of this process.

Methods

A Pubmed database search using as keywords “auditory

hallucinations”, “deaf” and “deafness” and retrieved papers were

selected according to their relevance.

Results

The authors report a case of a 47-year-old female patient

apparently suffering from congenital deafness. The patient had no

previous psychiatric history until 4 months prior to her admission

at our institution, when she started having psychotic symptoms.

The patient was admitted into a Neurology ward but because no

neurological sign was found psychiatric liaison consultation was

requested. Four months later, she had the same symptoms, describ-

ing a voice that said to “shut up” and was admitted to a psychiatric

hospital. After medication, the symptoms relapsed and now she is

followed in an outpatient setting.

The presence and nature of auditory hallucinations in deaf patients

is not fully elucidated and there are methodological problems in

the investigation of this subject.

Conclusions

Current evidence is still inconclusive and the fact

that prelingually deaf patient hear voices needs further research.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1952

EV968

“Yo Soy La Desintegración”:

Helplessness and sublimation through

Frida Kahlo’s history

J. Becker

Coimbra, Portugal

Considering the relevance of studying the pathologies of emptiness

for contemporaneous clinic, this work approaches the correlation

between helplessness and sublimation concepts. Helplessness is

considered a new theory, developed by David Maldavsky that uses

the term

desvalimiento

to define a clinical condition described by

the feeling of emptiness. To understand this concept, it is neces-

sary to return to a primitive period, when the baby is beginning

to qualify his affections. Thus, using historical construction, we

start at Freud’s works (focusing in the primitive period and the

affections qualification), explore the “good-enoughmother” impor-

tance, from Winnicott, and reaching the helplessness from the

present-days Maldavsky’s studies. The Frida Kahlo’s history illus-

trates this work as much because of her toxic current as because

of her talent to sublimate. The maternal failure, the toxic rela-

tionships, the trauma’s imposition, the abuse of alcohol and drugs

and the viscosity denounce her helplessness. Nevertheless, the art

expresses her fight for life. The Frida Kahlo’s works represent her

suffering, but they also are her attempts to understand her feel-

ings and to reframe her traumatic events. Therefore, we introduce

the sublimation as an alternative to the helplessness. Although

helplessness is the lack of the symbolic life, we present the art

as an opportunity to confront experiences, which can allow the

representation of the traumas and the qualification of affections.

Through the sublimation, Frida Kahlo recreated her inner world

and returned to life.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1953