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S654

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Introduction

The prevalence and impact of allergic diseases con-

tinues to grow, yet the etiology remains unclear. Adverse childhood

experiences (ACEs) have shown to influence the risk of various

chronic diseases, but little research has been done on the risk of

allergic diseases, and only on asthma.

Objective

To conduct a prospective study that assess the relation-

ship between ACE and risk of various allergic diseases.

Aims

To examine the association between ACE and risk of allergic

diseases in the context of: (1) relevant ACE and allergic disorder

grouping; (2) temporal association; (3) dose-response relationship.

Methods

A prospective population-based study linking Danish

register data on 1.1 mio parent-child pairs. With objectives, mea-

sures of ACE and allergic diseases survival analyses with relevant

covariates adjusting will be used to estimate relative risk of allergic

diseases when exposed to ACE.

Results

This studywill provide results on the relative risk of aller-

gic diseaseswhen exposed toACE compared to thosewithout, while

also describing the temporal and dose-reponse of the relationship.

Conclusion

This preliminary study will help to further advance

our understanding on ACE influence on physical health, specifi-

cally in regards to immune-related disorders. As such, this study

may help to build a framework for future prevention and treatment

initiatives of allergic disorders.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1938

EV954

Isolated psychiatric presentation of

anti N-methyl-

d

-aspartate receptor

encephalitis: A case report

P. Azevedo

1 ,

, F. Monteiro

1

, A.P. Correia

2

, A. Norton

1

,

A.M. Moreira

1

1

Magalhães Lemos hospital, inpatient unit C, Porto, Portugal

2

Magalhães Lemos hospital, department of neurology, Porto, Portugal

Corresponding author.

Introduction

Anti N-Methyl-D-Aspartate receptor (NMDAR)

encephalitis is an autoimmune disorder with a presentation that

includes acute behavioral changes, psychosis, cognitive impair-

ment and autonomic instability. In some cases, there are isolated

psychiatric symptoms without neurological involvement.

Aims

To raise awareness of the disorder among psychiatrists,

considering it a differential diagnosis in a first psychotic episode

since a prompt diagnosis and treatment can dramatically affect the

outcome.

Objectives

To summarize the latest literature about this field and

to present a case report.

Methods

A brief review of the latest literature was performed on

PubMed using the keywords “anti N-methyl-D-aspartate receptor

encephalitis”, “anti-NMDA encephalitis”, “psychiatric symptoms”.

Results

A 20-year-old male was admitted to our inpatient unit

with bizarre delusions of grandious and religious content, somatic

hallucinations, sleep cycle inversion and strange behaviour. These

symptoms had been present for 1 week and remitted after 10

days of treatment with risperidone. On follow-up, he developed

anhedonia, apathy and blunt affect. Brain MRI showed multiple

hyperintense changes in T2 and T2-FLAIR, highly suggestive of

demyelinating lesions. The cerebrospinal fluid showed mild lym-

phocytic pleocytosis, mildly increased proteins, oligoclonal bands

and anti-NMDAR antibodies of intrathecal production. He was

treated with corticoids and the antipsychotic was discontinued. No

neurologic symptoms were ever present.

Conclusion

This is an atypical case of anti-NMDAR encephali-

tis because of its isolated psychiatric presentation. Most patients

develop neurological symptoms 2 to 3 weeks after onset of psychi-

atric symptoms. Monosymptomatic syndromes arise in less than

5% of patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1939

EV955

A phenotype of resiliency?

Cross-sectional psychobiological

differences between caregivers who

are vulnerable vs. resilient to

depression, and controls

F.S. Bersani

1 ,

, O. Wolkowitz

2

, E. Epel

2

1

Sapienza university of Rome, department of neurology and

psychiatry, Roma, Italy

2

University of California San Francisco, department of psychiatry,

San Francisco, USA

Corresponding author.

Introduction

Being a caregiver of chronically ill children is a

source of chronic-psychological stress affecting general physi-

cal and mental health. However, there is tremendous variance

among caregivers: some may develop stress-related depression,

whereas others are more “resilient”. The objective of the study was

to phenotypically differentiate on psychobiology caregivers who

developed depressive symptoms (“vulnerable”) vs. those who did

not (“resilient”) from each other and from age-matched controls.

Methods

Forty-five mothers of chronically-ill children and 18

controls have been examined. Caregiverswere divided via amedian

split of Center for Epidemiological Studies Depression Scale scores

in “resilient” (RCs) and “vulnerable” (VCs). We assessed cogni-

tive, affective, metabolic, neuroendocrine and oxidative markers at

rest and in response to a laboratory social stressor. ANCOVAs and

Bonferroni post-hoc tests were used to examine between-group

differences.

Results

Although RCs compared to VCs had similar levels of

objective parenting-related burden (

P

= 0.51), they had lower sub-

jective distress (

P

< 0.01) and higher levels of positive affect

(

P

= 0.04). Although RCs compared to controls had higher levels

of objective parenting-related burden (

P

= 0.04), they had greater

cortisol suppression post-dexamethasone (

P

= 0.05), lower F2-

isoprostanes/vitamin E ratio (

P

< 0.01) and lower fasting insulin

levels (

P

= 0.06).

Discussion

Our results suggest that caregivers with higher

resiliency demonstrate more salutary stress-related functioning in

comparison with less resilient caregivers and, more surprisingly,

non-caregiver controls. These findings might be interpreted in the

spirit of Nietzsche’s quote “

What does not kill me, makesme stronger

and of the idea that successfully overcoming adversitymay bemore

psychobiologically beneficial than not having been exposed to any

adversity.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1940

EV956

Psychiatric symptoms as onset of

anti-NMDAR encephalitis

M.C. Cancino Botello

1 ,

, A. Cercos López

2

, V. Chavarria Romero

3

,

G. Sugranyes Ernest

4

1

Consorcio hospital general universitario, psychiatry, Valencia, Spain

2

Hospital universitario de Santa María, psychiatry, Lleida, Spain

3

Hospital del Mar, psychiatry, Barcelona, Spain

4

Hospital clinic, psychiatry, Barcelona, Spain

Corresponding author.

Introduction

Every more often, there is evidence that shows a

relationship between psychiatric symptoms and autoimmune dis-

orders. Such is the case of anti-NMDAR encephalitis, in which it