European Psychiatry - Volume 33 - March 2016

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S586 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
EV738
Depression in geriatric inpatients:
Correlations with nutritional state
and cognitive functions
I. Bonfitto , G. Moniello , L. Ariano , M. Pascucci ∗,
M.D. Zanasi , A. Bellomo
1 University of Foggia, Institute of Psychiatry, Foggia, Italy
2 Ospedali Riuniti di Foggia, Department of Geriatric Medicine,
Foggia, Italy
∗ Corresponding author.
Background Although the prevalence of malnutrition is relatively
low among elderly people, the risk increases significantly among
inpatients and even more in those with mental deterioration.
Aims To evaluate the possible association between the severity
of depressive symptoms, the nutritional status and the cognitive
decline in a sample of geriatric inpatients.
Methods Fifty-one geriatric inpatients completed the following
tests:
– HamiltonDepression Rating Scale (HAM-D), to assess the severity
of depressive symptoms;
– Mini Nutritional Assessment (MNA), as a nutrition screening and
assessment tool;
– Mini Mental State Examination (MMSE), to assess the cognitive
impairment.
Results There is a negative proportional relationship between
HAM-D and MMSE scores (P = 0.001) and between HAM-D and
MNA scores (P = 0.023). Depressed patients found to have a greater
cognitive impairment and a worse nutritional status. Considering
a HAM-D cut-off point of 14, distinguishing mild than moderate
depression, it shows a significant correlation with the MNA scores
(P = 0.008). Patients with HAM-D scores ≥ 14 have an average MNA
score of 19.8, while patients with HAM-D scores < 14 have an MNA
average score of 23.6. Euthymic or mildly depressed patients are
not at risk of malnutrition, while those with moderate or severe
depression have an increased risk of malnutrition.
Conclusions Our study shows significant correlations between
the severity of depressive symptoms and the risk of malnutrition
or cognitive impairment. A mild depression state does not seem to
be associated with an increased risk of malnutrition.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV739
Neuropsychological and motivational
factors of cognitive efficiency in
elderly patients with essential arterial
hypertension
E. Pervichko ∗, Y. Zinchenko , O. Ostroumova
1 Lomonosov Moscow State University, Faculty of Psychology,
Moscow, Russia
2 Moscow State University of Medicine and Dentistry, Faculty of
General Medicine, Moscow, Russia
∗ Corresponding author.
Introduction The diagnostics of cognitive disorders (CD) in
patients with essential arterial hypertension (EAH) is often nec-
essary for the choice of treatment strategy.
Objective To assess the role of neuropsychological and motiva-
tional factors in cognitive efficiency of elderly EAH patients.
Materials and methods Twenty-five patients with EAH took part
in the study, stage 1–2, mean age was 67.6 ± 6.1. The assessment
of cognitive functions embraced a quantitative measurement of
intelligence quotient (IQ) with the Wechsler Adult Intelligence
Scale (Wechsler, 1955), and investigation into qualitative features
of cognitive processes with Luria’s neuropsychological assessment
scheme (Luria, 1980) and Zeigarnik’s procedure of pathopsycho-
logical study (Zeigarnik, 1972).
Results Within the psychological syndrome structure of CD in
EAH patients the leading part is played by the neuro-dynamic
factor, manifested in general lability, slowing down, and sud-
den exhaustion caused by reduction in energy of mental activity.
The conclusion is supported by the high frequency of described
symptoms among EAH patients and low dynamics of their reduc-
tion against the antihypertensive therapy (Pervichko et al., 2014,
2015). However, performance of experimental tasks makes 30% of
EAH patients reveal reduced motivation. They would achieve poor
results in general scoring, if compared with the group of highly
motivated participants. Correlation analysis data show the inter-
connection between frequency disturbances in motivation and
frequency in occurrence of various signs of cognitive decline, such
as low efficiency inmemorization and delayed recall, as well as low
IQ indices.
Conclusions The data provide a strong argument to support the
hypothesis of particular importance of motivational factor of cog-
nitive efficiency in elderly EAH patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV740
Case-report and review of selective
serotonin reuptake
inhibitors-induced delirium in older
adults
S. Petrykiv ∗, L. de Jonge , M. Arts
1 GGZ Friesland, Psychiatric Emergency, Leeuwarden, Netherlands
2 UMC Groningen, Epidemiology, Groningen, Netherlands
3 UMC Groningen, Old Age Psychiatry, Groningen, Netherlands
∗ Corresponding author.
Introduction Selective serotonin reuptake inhibitors (SSRIs) are
the most widely prescribed antidepressants with generally fewer
side effects than most other types of antidepressants. However, in
frail elderly, the use of SSRIs was anecdotally reported as a potential
cause of a delirium.
Objectives To present a case of citalopram-induced delirium in
an older adult diagnosed with late-life depression.
Aims To review available literature on SSRI-induced delirium.
Methods A case report is presented and discussed, followed by a
literature review.
Results Seven published cases of SSRI-induced delirium in older
adults (> 60 years) were found while searching through Pubmed
and Embase. Our case of a 75-year-old female is also included in
this report. This patient was ambulatory treated with citalopram
20mg per os against depressive symptoms and she developed a
delirium four days after the initiation of the therapy. Blood tests
were normal and CT scan showed no significant findings. No other
medical evidence was found that could explain her delirium. Her
symptoms finally resolved after discontinuation of citalopram.
Conclusion The on- and off-treatment side-effect correlation by
a segregate oral use of citalopram strongly suggests that SSRIs may
have the potential to cause a delirium, especially in frail elderly.
Further research on this topic is needed.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.