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S60

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S56–S71

Over the last decade, the “traditional” drug scene has been sup-

plemented – but not replaced – by the emergence of a range of

novel psychoactive substances (NPS), which are either newly cre-

ated or existing drugs, including medications, now being used in

novel ways. By the end of 2015, in excess of 700 NPS had been

reported by a large number of countries in the world. Most recent

data show however that synthetic cathinones; synthetic cannabi-

noids; and psychedelics/phenethylamines; account for the largest

number of NPS. Given the vast range of medical and psychopatho-

logical issues associated with the molecules here described, it is

crucial for health professionals to be aware of the effects and tox-

icity of NPS. The “Drugs 2.0.” revolution facilitated the birth and

growth of an “Online Drug Culture” which finds its main expres-

sion in chats/fora/blogs as well as the diffusion of online drug

marketplaces (both in the surface and deep web). The web has pro-

gressively modified the drug market from a “street” into a “virtual”

one, so by increasing the availability of newdrugs/NPS/“legal highs”

(“legal alternatives” to the traditional illegal drugs). The rapid pace

of change in the NPS online market constitutes a major challenge to

the provision of current and reliable scientific knowledge on these

substances. The present lecture aims at providing an overview of

the NPS phenomenon, also giving an overview of the main clini-

cal and pharmacological issues relating to these most popular NPS

categories.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.945

W12

Translational perspectives in

addiction psychiatry

A. Schellekens

Radboud University Medical Centre, Donders Centre for

Neuroscience, department of Psychiatry, Nijmegen Institute for

Scientist Practitioners in Addiction, Nijmegen, Netherlands

Background

Heritable factors account for approximately 50–60%

of the risk for alcohol dependence. However, which genes confer

this risk remains to elucidate. Moreover, genetic association studies

are hampered by non-replication. Several strategies can be applied

to approach this issue. One option is the application of intermedi-

ate phenotypes. Neurobiological measures that are closely related

to the addiction phenotype may be more directly related to genetic

variation. Intermediate phenotypes related to dopamine function

seem particularly suitable, given the strong dopamine hypothesis

in addiction. Another strategy is to include environmental factors,

such as childhood adverse experience, in genetic association stud-

ies. We tested the effect of

COMT

Val158Met and

DRD2

Taq1A

genotypes, as modulators of brain dopamine function in the con-

text of self-reported environmental factors, like childhood adverse

experience.

Methods

Alcohol-dependent patients (

n

= 110) and healthy con-

trols (

n

= 99) were genotyped for the

COMT

Val158Met and

DRD2

Taq1A genotypes. Childhood adversity was measured using self-

report questionnaires. Dopamine sensitivity was assessed using an

apomorphine challenge with cognitive performance and plasma

growth hormone levels as main outcome measures.

Results COMT

genotype modulated the effect of apomorphine on

cognitive performance, but was not directly associatedwith alcohol

dependence. Yet, the interaction between childhood adversity and

COMT

genotype did predict alcohol dependence.

DRD2

genotype

modulated the effect of apomorphine on plasma growth hormone

levels and was also not directly associated with alcohol depend-

ence. Yet, the interaction between parental rule setting and

DRD2

genotype did predict alcohol use in a separate population-based

sample of adolescents.

Conclusion

This study provides evidence for a role of

COMT

and

DRD2

genotypes in alcohol dependence using both the GxE and

intermediate phenotype approach. This confirms that both an inter-

mediate phenotype approach and GxE interaction analyses can

be useful tools in understanding mechanisms mediating addic-

tion vulnerability. The clinical relevance of dopamine genes and

intermediate phenotypes for staging and profiling of alcohol use

disorders remains to be investigated.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.946

Getting started: The first steps in psychiatric

consultations

W13

Short-term psychotherapeutic

interventions in consultation-liaison

psychiatry

A. Diefenbacher

, R. Burian

Ev. Krankenhaus-Königin Elisabeth Herzberge gGmbH, Psychiatry,

Psychotherapy and Psychosomatic, Berlin, Germany

Corresponding author.

Due to a reduction in length of hospital stay of general hospi-

tal inpatients, CL-psychiatrists find themselves confronted with

the problem of “less time to do more”. This presentation will

first outline procedural aspects of CL-psychiatry, delineating its

development from the “situational approach” do becoming case

managers. Then, short-term supportive interventions will be dis-

cussedwith regard to their applicability andnewer disorder specific

techniques, such as ACT and DBT will be demonstrated in their

usefulness for the medically ill.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.947

W14

The magic list of everyday problems in

consultation-liaison psychiatry (and

hints for solving them)

S. Ferrari

, G. Mattei , G.M. Galeazzi , M. Rigatelli

University of Modena & Reggio Emilia, Department of

Diagnostic-Clinical Medicine and Public Health, Modena, Italy

Corresponding author.

Introduction

Consultation-liaison psychiatry (CLP) deals with

clinical, research and training activities at the interface between

psychiatry and the rest of medicine. The main clinical competen-

cies of CLP include medical-psychiatric comorbidity (co-existing

psychiatric and non-psychiatric disorders affecting reciprocally);

medically unexplained physical symptoms, “somatization” and

functional disorders; and liaison activities, addressed to medical

workers and teams.

Objectives/aims

To describe and discuss typical clinical scenar-

ios that CL psychiatrists have to work in, and suggest effective,

evidence-based solutions.

Methods

Long-standing everyday clinical experience of the

authors combined to evidence derived from international literature

consented to create a list of the most common and complex prob-

lems or difficulties typical of the CLP clinical context, and related

possible solutions.

Results

Most common/complex problems include the following:

stigma and prejudice (of patients, relatives, colleagues, and own);

excessive technicality of language; short/unpredictable duration of

hospital stay of patients, and more in general pressure in clinical