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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S547

EV617

Insight and aggressive behavior in

acute schizophrenic patients

S. Campi

1 ,

, C. Esposito

2

, P. Andreassi

3

, P. Bandinelli

3

,

P. Girardi

4

, G. Ducci

5

, C. Cannizzaro

5

, C. Cacciari

2

, G. Spalletta

6

1

Rome, Italy

2

IRCCS Santa Lucia Fondation, Neuroscience, Rome, Italy

3

SPDC San filippo Neri ASL RmE, Mental Health Department, Rome,

Italy

4

Sant’Andrea hospital Sapienza University, Mental Health, Rome,

Italy

5

SPDC San Filippo Neri ASL RmE, Mental Health, Rome, Italy

6

IRCCS Santa Lucia foundation, Neuroscience, Rome, Italy

Corresponding author.

Introduction

Aggressive behavior in wards is associated to poor

treatment compliance and low clinical insight. Most studies

focused on the clinical and cognitive dimensions of insight, while

the relationship between metacognitive dimension and aggres-

sive behaviors was not investigated. Our aim was to understand

what relationship occurs between dimensions of insight (metacog-

nitive, cognitive, clinical), and specific aggressive behaviors in acute

patients.

Methods

We recruited 75 acute schizophrenic patients using:

AQ; MOAS; IS; PANSS; BCIS.

Results

A positive correlation between the IS score and the hos-

tility, angry and physical aggression sub-scores of the AQ was

highlighted, while no correlation between the score of IS andMOAS

total score was found. No correlation between the score of the

PANSS G12 item and the AQ scores and MOAS was found, and no

correlation between BCIS scores, MOAS and AQ scores was found.

Conclusions

In our patients, a higher level of metacognitive

insight, but not clinical nor cognitive insight, was associated to

higher levels of hostility. We suggest that a higher ability to moni-

tor and appraise one’s own altered processes of thought and related

discomfort, feeling of destabilization and loss of control, could con-

tribute to enhance resentment and suspiciousness. Findings help

develop specific therapeutic strategies to enhance metacognitive

and self-monitoring abilities, helping patient’s understanding of

the illness, improving compliance with treatment, and patient’s

quality of life. Our results support the multidimensional nature

of insight in schizophrenia, confirming that clinical, cognitive and

metacognitive dimensions are independent though related facets

of the phenomenon of insight in schizophrenia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1602

EV618

Loxapine for agitation in psychiatric

patients who consult in emergency

medical services

M.Á. Carrillo

, M.J. Martínez , P. Botías , I. Imbernón ,

M. Martínez-Carlón , M. Fueyo , C. Calero , N. Megias , S. Pina ,

M. Gavilan , M.P. Sanchez , J. Sanchez , P. Chacon

University Hospital of Murcia Virgen Arrixaca, Psychiatry, Murcia,

Spain

Corresponding author.

Introduction

The DSM-5 defines psychomotor agitation as exces-

sive motor activity associated with a feeling of inner tension. The

activity is usually nonproductive and repetitious and consists of

behaviors such as pacing, fidgeting, wringing of the hands, pulling

of clothes, and inability to sit still. This kind of behavoir occurs in up

to 25% of psychiatrics patients who consult in emergency medical

services.

Objective

The main objective was to determine the efficacy of

loxapine inhalation powder in acute agitation.

Methods

Ten agitated psychiatric patients scored Positive and

Negative Syndrome Scale – Excited Component (PANSS-EC) base-

line and ten minutes after the administration of ADASUVE

®

.

Results

The efficacy of loxapine 10mg in the acute treatment of

agitation was established in a short-term (10minutes).

Conclusions

Loxapine is the first and only orally inhaled med-

ication for the acute treatment of agitation associated with

psychiatrics disorders, which is a tool easy-to-use in emergency

medical services.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1603

EV619

Change of mood in relation with the

seasons

R. de la Mata Hidalgo

1 ,

, M. de la Mata Hidalgo

2

,

I. Valriberas Herrera

1

, O.E. Ana

1

, L. Al Chaal Marcos

1

,

C. González Soria

1

, L. Sánchez Pernas

1

, C. Exposito Montes

2

1

Instituto de Investigación Biomédica de Salamanca, Psychiatry,

Salamanca, Spain

2

Facultad Medicina Córdoba, Psychiatry, Córdoba, Spain

Corresponding author.

Introduction

Emergency situations related to mental disorders

represent a significant proportion of all medical emergencies. Over

the last years we have been witness to an upturn in the incidence

of psychiatry emergency service because to change of mood.

Objective

To determine the profile of the patient who requires

psychiatric attentionwith changing of mood in our area in different

seasons.

Methodology

This is a prevalence and prospective study in which

the dependent variable is taken as change of mood and we also use

three more independent variables that are age sex and seasonality.

The seasonality (spring period and summer period) will be at the

same time the form of divided the population in two groups to

compare.

Results

Out of all the consultations for changing of mood in the

emergency service during the first period (113 patients), 34% were

men and 66% were women. The age range of 36–50 years was more

frequent for women and the age range of 51–65 years was more

frequent for men. In the second period (with 162 patients), 137

women (86%) and 25 men (14%). In this case, the most common

age range was 36–50 years, both for women and for men.

Conclusions

The epidemiological and clinical characteristics of

patients with changing of mood assessed by the emergency service

are described from a naturalistic approach.

Which Chi

2

we will discover if the population who has been taken

between woman and man is significant and with the median, we

will also determine if the age ranges are enough significant to con-

firm our hypothesis.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1604

EV620

Atypical psychosis in emergency: A

case review

A. Espinosa Benavides

1 ,

, C . S

anahuja Mu˜noz

2

1

Instituto Psiquiátrico José Germain, Psiquiatría, Leganés, Spain

2

Hospital Universitario de Fuenlabrada, Psiquiatría, Fuenlabrada,

Spain

Corresponding author.

The authors describe the presentation of a case of atypical psy-

chosis in the emergency services, and describe the unusual clinical

features of manifestation of psychotic disorders.