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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S18–S55

S45

self-evaluation task. The task comprised a self-reflection, close

other-reflection, and a semantic (baseline)

condition.We

compared

correlates of Expressive versus Social amotivation factors (summed

items from the PANSS interview) for the contrasts self-baseline and

self-other. Significance threshold was set at

P

< 0.05 family-wise

error (FEW) corrected.

Results

Social amotivation correlated significantly with self-

evaluation vs. baseline in right and left ACC, and in the sulcus of

frontal lateral lobe between inferior frontal triangularis and mid-

dle frontal gyrus. This was also significant, but less pronounced, in

the direct comparison of social amotivation vs. expressive deficits

scores (for the self-baseline contrast). No activation differences sur-

vived critical thresholds for the self-other contrast.

Conclusion

Differential neural correlates for the two dimensions

of negative symptoms support the validity of this distinction based

on factor analyses. Intact functioning of brain circuitry for self-

referential processing may be of relevance to actively seek social

interaction.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.900

S85

The social self in schizophrenia: A

neural network perspective on

integrative external and internal

information processing

S. Ebisch

University G. d’Annunzio, Department of Neuroscience and Imaging,

Chieti, Italy

Social impairment is recognized as a basic aspects of schizophre-

nia. Although the nature of aberrant self-other relationship in

schizophrenia is still poorly understood, it has been suggested that

some social impairments could have their roots in self-disturbances

typical of schizophrenia. For instance, experiencing otherness could

become problematic with anomalous self-recognition. Further-

more, deficits in the processing of self-relatedness of social stimuli

disconnect the self from its social environment. On the one hand,

this could lead to problems in self-other distinction caused by

misattributions of ownership of experience and agency in social

interaction. On the other hand, this could result in feelings of

isolation and reduced intersubjectivity due to interrupted self-

referential processing of social stimuli, likely also mediated by

memory and emotion. Brain networks involved in self-referential

processing, sense of ownership, and agency also have been implied

in social cognition. Whereas cortical midline structures are associ-

ated with self-referential processing of external stimuli including

social information, sensorimotor and affective networks involved

in bodily and interoceptive self-processing are also involved in the

ability to share others’ experiences. Schizophrenia has been linked

with a reduced integrity of these networks underlying various

aspects of self and social impairments, though rather separately.

Recent neuroimaging findings will be highlighted explaining how

self-disturbances can pervade the social domain in schizophrenia.

In particular, disruptions of the social self in schizophrenia will be

addressed froma neuronal network and connectiomics perspective

providing a unifying framework.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.901

S86

Psychopathology of the self and the

altered cortical midline structures in

psychiatric disorders – a marriage?

G. Northoff

University of Ottawa, Institute of Mental Research, Ottawa, Canada

The self is central in our mental life and disturbances of the self-

figure most prominently in psychopathological symptoms. The

cortical midline structures (CMS) have been associated with self-

related processing and its changes in schizophrenia, depression and

other psychiatric disorders. However, the exact neuronal mecha-

nisms underlying self-related processing in CMS and its changes in

psychiatric disorders remain unclear. Especially the neural over-

lap between high resting state activity levels and self-related

processing in CMS is rather puzzling. I present recent data on the

rest-self overlap in healthy subjects showing that resting state

activity in CMS can predict self-relatedness. The implications for

psychological symptoms as in depression and schizophrenia are

pointed out.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.902

S87

Brain networks sub-serving

self-referential processing in

depression

G. Wagner

, C. Schachtzabel , G. Peikert , K.J. Bär

Jena University Hospital, Psychiatry and Psychotherapy, Jena,

Germany

Corresponding author.

Introduction

Persistent pondering over negative self-related

thoughts is a central feature of depressive psychopathology.

Objectives

In the present study, we sought to investigate the neu-

ral correlates of abnormal negative self-referential processing (SRP)

in patients with major depressive disorder (MDD) and its impact

on subsequent cognitive control-related neuronal activation.

Aims

We hypothesized aberrant activation dynamics during the

period of negative and neutral SRP in the rostral anterior cingu-

late cortex (rACC) and in the amygdala in patients with MDD. We

assumed abnormal activation in the fronto-cingulate network dur-

ing Stroop task execution.

Methods

Nineteen depressed patients and 20 healthy controls

participated in the study. Using an event-related fMRI design,

negative, positive and neutral self-referential statements were dis-

played for 6.5s and followed by incongruent or congruent Stroop

conditions.

Results

In contrast to controls, patients did not exhibit valence-

dependent rACC activation differences during SRP. A novel finding

was the significant activation of the amygdala and the reward-

processing network during presentation of neutral self-referential

stimuli relative to baseline and to affective stimuli in patients. The

fMRI analysis of the Stroop task revealed a reduced BOLD activation

in the right frontoparietal network of patients in the incongruent

condition after negative SRP only.

Conclusions

Thus, the inflexible activation in the rACC may

correspond to the inability of depressed patients to shift their atten-

tion away from negative self-related stimuli. The accompanying

negative affect and task-irrelevant emotional processing may com-

pete for neuronal resources with cognitive control processes and

lead thereby to deficient cognitive performance associated with

decreased frontoparietal activation.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.903