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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S18–S55

S41

The accurate identification of accelerated, agitated and anxious

states is of paramount relevance for the correct diagnosis and the

selection of a suitable psychopharmacological treatment. Choos-

ing antidepressants, antipsychotics and/or mood stabilizers is

presently contingent to the identification of specific phenotypic

profiles in anxiety disorders, mixed and manic episodes and/or

delirium states. Today, the anamnesis and psychopathological

examination are hindered by the vagueness of the concep-

tualization of these experiences in diagnostic textbooks. We

propose a selective review of literature of how these have been

conceptualised aiming at increasing the segregation of specific

phenomenological profiles across these phenomena.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.887

S72

Phenomenology of emotions

G. Stanghellini

1 ,

, M. Aragona

2

, O. Doerr-Zegers

3

,

M. Musalek

4

, L. Madeira

5

1

“G. d’Annunzio” University, Department of Psychological,

Humanistic and Territorial Sciences, Chieti, Italy

2

Sapienza University, Philosophy, Rome, Italy

3

Portales University, Psychiatry, Santiago del Chile, Chile

4

Anton Proksch Institute, Psychiatry, Vienna, Austria

5

University of Lisbon, Psychiatry, Lisbon, Portugal

Corresponding author.

This symposium analyses the psychopathological phenomenon

“anxiety”, a classical concept, which has returned to be central in

the recent psychiatric debate. Some of the most important inter-

national phenomenologists will discuss anxiety in the context of

major psychopathological areas. Clinical and research insight will

be presented in the context of a philosophically deep understand-

ing of the fundamental qualitative features of the psychopathology

of anxiety.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.888

Physical activity for people with psychotic

disorders: Realities and prospects

S73

Studies on PA in schizophrenia: What

did we learn? What is effective?

G. de Girolamo

, V. Bulgari

Saint John of God Clinical Research Center, Psychiatric Epidemiology

and Evaluation Unit, Brescia, Italy

Corresponding author.

Schizophrenia is frequently associated with abnormal physical

activity (PA) per se (e.g., hypokinesia, motor retardation, etc.) or

related to antipsychotic medications (e.g., extrapyramidal symp-

toms including bradykinesia, tremor, etc.). Daily amounts of PA for

subjects diagnosedwith schizophrenia tend to decrease over the ill-

ness course and contribute tometabolic and cognitive disturbances.

PA intervention for schizophrenia patients may result in increased

well-being, improved cognitive functioning, fewer negative symp-

toms and increased self-efficacy, leading to improvedmanagement

of psychosocial life domains. However, PA trials conducted among

people suffering from schizophrenia show several methodological

limits: small sample sizes, lack of randomized patients’ allocation,

heterogeneity of interventions and inappropriate outcome meas-

ures.

Firth et al. (2015) have recently conducted a systematic review

and meta-analysis of 11 trials on structured PA in schizophrenia

(

n

= 659, median age of 33 years). The conclusions of this recent

review are the following:

– aerobic exercise (for instance exercise bike) of moderate-to-

vigorous intensity done at least 90minutes per week is effective in

improving cardiovascular fitness; studies (

n

= 7) using VO

2max

as an

assessment of fitness have reported clinically significant increases

in VO

2max

, “defined as sufficient to reduce cardiovascular disease

risk by 15% and mortality by 20%”;

– several low-dose aerobic interventions did not shown any effect;

– there was a “strong effect of exercise on total psychiatric symp-

toms” (both positive and negative symptoms were reduced);

– total attrition rate was 32%. Group exercise showed amuch lower

attrition rate than solitary exercise;

– caregivers’ supervision increased compliance as compared to

unsupervised intervention;

– in the only study that compared per-protocol and intention-

to-treat analysis, a significant improvement in fitness, psychiatric

symptoms and overall functioning only occurred in participants

who attended > 50% of exercise sessions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.889

S74

Clinical and neurobiological effects of

aerobic endurance training in

multi-episode schizophrenia patients

P. Falkai

Department of Psychiatry, Ludwig-Maximilians-University, Munich,

Germany

Schizophrenia is a severe brain disorder characterised by positive,

negative, affective and cognitive symptoms and can be viewed

as a disorder of impaired neural plasticity. Aerobic exercise has

a profound impact on the plasticity of the brain of both rodents

and humans such as inducing the proliferation and differentia-

tion of neural progenitor cells of the hippocampus in mice and

rats. Aerobic exercise enhances LTP and leads to a better per-

formance in hippocampus related memory tasks, eventually by

increasing metabolic and synaptic plasticity related proteins in

the hippocampus. In healthy humans, regular aerobic exercise

increases hippocampal volume and seems to diminish processes

of ageing like brain atrophy and cognitive decline.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.890

S75

Feasibility and effectiveness of aerobic

exercise training interventions in

schizophrenia

K. Keller-Varady

1 ,

, A. Hasan

1

, T. Schneider-Axmann

1

,

U. Hillmer-Vogel

2 , B. A

domßent

2 , T. W

obrock

3 , A. S

chmitt

1 ,

A. Niklas

2 , P. F

alkai

1 , B. M

alchow

1

1

Ludwig-Maximilians-University, Department of Psychiatry and

Psychotherapy, Munich, Germany

2

University Medical Center Göttingen, Department of Sports

Medicine, Göttingen, Germany

3

University Medical Center Göttingen, Department of Psychiatry and

Psychotherapy, Göttingen, Germany

Corresponding author.

Patients with schizophrenia might benefit from exercise via

multiple ways. It can be assumed that positive effects observed

in healthy people counteract different pathological dimensions of