European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S18–S55 S41
The accurate identification of accelerated, agitated and anxious
states is of paramount relevance for the correct diagnosis and the
selection of a suitable psychopharmacological treatment. Choos-
ing antidepressants, antipsychotics and/or mood stabilizers is
presently contingent to the identification of specific phenotypic
profiles in anxiety disorders, mixed and manic episodes and/or
delirium states. Today, the anamnesis and psychopathological
examination are hindered by the vagueness of the concep-
tualization of these experiences in diagnostic textbooks. We
propose a selective review of literature of how these have been
conceptualised aiming at increasing the segregation of specific
phenomenological profiles across these phenomena.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
S72
Phenomenology of emotions
G. Stanghellini ∗, M. Aragona , O. Doerr-Zegers ,
M. Musalek , L. Madeira
1 “G. d’Annunzio” University, Department of Psychological,
Humanistic and Territorial Sciences, Chieti, Italy
2 Sapienza University, Philosophy, Rome, Italy
3 Portales University, Psychiatry, Santiago del Chile, Chile
4 Anton Proksch Institute, Psychiatry, Vienna, Austria
5 University of Lisbon, Psychiatry, Lisbon, Portugal
∗ Corresponding author.
This symposium analyses the psychopathological phenomenon
“anxiety”, a classical concept, which has returned to be central in
the recent psychiatric debate. Some of the most important inter-
national phenomenologists will discuss anxiety in the context of
major psychopathological areas. Clinical and research insight will
be presented in the context of a philosophically deep understand-
ing of the fundamental qualitative features of the psychopathology
of anxiety.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Physical activity for people with psychotic
disorders: Realities and prospects
S73
Studies on PA in schizophrenia: What
did we learn? What is effective?
G. de Girolamo ∗, V. Bulgari
Saint John of God Clinical Research Center, Psychiatric Epidemiology
and Evaluation Unit, Brescia, Italy
∗ Corresponding author.
Schizophrenia is frequently associated with abnormal physical
activity (PA) per se (e.g., hypokinesia, motor retardation, etc.) or
related to antipsychotic medications (e.g., extrapyramidal symp-
toms including bradykinesia, tremor, etc.). Daily amounts of PA for
subjects diagnosedwith schizophrenia tend to decrease over the ill-
ness course and contribute tometabolic and cognitive disturbances.
PA intervention for schizophrenia patients may result in increased
well-being, improved cognitive functioning, fewer negative symp-
toms and increased self-efficacy, leading to improvedmanagement
of psychosocial life domains. However, PA trials conducted among
people suffering from schizophrenia show several methodological
limits: small sample sizes, lack of randomized patients’ allocation,
heterogeneity of interventions and inappropriate outcome meas-
ures.
Firth et al. (2015) have recently conducted a systematic review
and meta-analysis of 11 trials on structured PA in schizophrenia
(n = 659, median age of 33 years). The conclusions of this recent
review are the following:
– aerobic exercise (for instance exercise bike) of moderate-to-
vigorous intensity done at least 90minutes per week is effective in
improving cardiovascular fitness; studies (n = 7) using VO 2max as an
assessment of fitness have reported clinically significant increases
in VO2max , “defined as sufficient to reduce cardiovascular disease
risk by 15% and mortality by 20%”;
– several low-dose aerobic interventions did not shown any effect;
– there was a “strong effect of exercise on total psychiatric symp-
toms” (both positive and negative symptoms were reduced);
– total attrition rate was 32%. Group exercise showed amuch lower
attrition rate than solitary exercise;
– caregivers’ supervision increased compliance as compared to
unsupervised intervention;
– in the only study that compared per-protocol and intention-
to-treat analysis, a significant improvement in fitness, psychiatric
symptoms and overall functioning only occurred in participants
who attended > 50% of exercise sessions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
S74
Clinical and neurobiological effects of
aerobic endurance training in
multi-episode schizophrenia patients
P. Falkai
Department of Psychiatry, Ludwig-Maximilians-University, Munich,
Germany
Schizophrenia is a severe brain disorder characterised by positive,
negative, affective and cognitive symptoms and can be viewed
as a disorder of impaired neural plasticity. Aerobic exercise has
a profound impact on the plasticity of the brain of both rodents
and humans such as inducing the proliferation and differentia-
tion of neural progenitor cells of the hippocampus in mice and
rats. Aerobic exercise enhances LTP and leads to a better per-
formance in hippocampus related memory tasks, eventually by
increasing metabolic and synaptic plasticity related proteins in
the hippocampus. In healthy humans, regular aerobic exercise
increases hippocampal volume and seems to diminish processes
of ageing like brain atrophy and cognitive decline.
Disclosure of interest The author has not supplied his declaration
of competing interest.
S75
Feasibility and effectiveness of aerobic
exercise training interventions in
schizophrenia
K. Keller-Varady ∗, A. Hasan , T. Schneider-Axmann ,
U. Hillmer-Vogel domßent obrock chmitt
A. Niklas alkai alchow
1 Ludwig-Maximilians-University, Department of Psychiatry and
Psychotherapy, Munich, Germany
2 University Medical Center Göttingen, Department of Sports
Medicine, Göttingen, Germany
3 University Medical Center Göttingen, Department of Psychiatry and
Psychotherapy, Göttingen, Germany
∗ Corresponding author.
Patients with schizophrenia might benefit from exercise via
multiple ways. It can be assumed that positive effects observed
in healthy people counteract different pathological dimensions of