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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S425

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1221

EV237

The evolution of cognitive functioning

in adolescents with early onset

psychosis

A. Bohus

Cluj-Napoca, Romania

Introduction

Cognitive deficits (executive functions, verbal and

spatial learning and memory, visual processing and attention) are

a fundamental trait of schizophrenia.

Objective

The main objective of this study is to compare the cog-

nitive functioning in psychotic adolescents at the psychosis onset

and after one year, using psychological tests.

Methods

This is a longitudinal study, during a period of two

years and a half. Twenty-eight patients with first psychotic episode

agreed to participate to this study and were assessed during their

hospitalization in a university clinic for child and adolescent psychi-

atry in Cluj-Napoca, Romania. The diagnosis was based on DSM-IV

criteria. All the patients were initially assessed for intelligence level

using Raven Test and those withmental retardationwere excluded.

After one year, sixteen adolescents from the initial group were

reassessed. The cognitive functioning was assessed with Trail Mak-

ing A and B, verbal fluency tasks, Wisconsin Card Sorting Test and

Rey Auditory Verbal Learning Test. The results from patients group

were compared with those from healthy controls.

Results

The results show weaker global cognitive performance

from adolescents with early onset psychosis, initially and at one-

year evaluation, than the healthy adolescents from the control

group.

Conclusions

This results are consistent with those of previous

studies. The adolescents with early onset psychosis show multi-

ple cognitive impairments initially and one year after the psychosis

onset.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1222

EV238

Gender dysphoria in USMIJ of Toledo.

Report of a case

P. González Rivera

1

, A. Hidalgo Borreguero

2 ,

,

S. Bola˜no Mendoza

3

, M. Soto Laguna

1

, K. Preckler Pe˜na

4

,

F.J. Gonzalez Díaz

5

, A. Zafra Villena

6

, M. Perez Castellanos

4

,

J. Prados Gómez

1

, P. Alvites Ahumada

1

, R. Perez Asenjo

1

,

A.J. Benito Ruiz

1

, A. Perez López

1

, E. Landa Contreras

1

,

M. Fernandez-Torija Daza

1

1

Hospital Provincial de la Misericordia, Psiquiatria, Toledo, Spain

2

USMIJ, Psiquiatria, Toledo, Spain

3

Hospital 12 de Octubre, Psiquiatria, Madrid, Spain

4

Hospital Virgen del Prado, Psiquiatria, Talavera, Spain

5

Hospital Virgen de la Salud, Psiquiatria, Toledo, Spain

6

IVANE, Psiquiatria, Valencia, Spain

Corresponding author.

The start of Child and Adolescent attention to gender dysphoria is

very recent. In our Unit, it has objectified a growing increase in such

demand over recent years.

As a typical example would be a patient of 13 years following

gender dysphoria begins to present school failure and behavior

problems at home with emotional instability.

According to the recommendations of the Group Identity and Sex-

ual Differentiation (GIDSEEN) after early detection is to guide

parents towards a comprehensive treatment at a specialized

interdisciplinary teams and a psychosocial approach to improve the

quality of life, decrease mental comorbidity and gender dysphoria

own. Having no such care in our community has been necessary to

make a referral to another community to attend this demand.

Currently it is giving adequate attention to these cases, but except

for referral to another community. However, as we are seeing pro-

gression care in our area in the future could be feasible. Therefore,

we consider as a first step dysphoria quantify each case in our area.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1223

EV239

Wernicke-Korsakoff syndrome with

psychotic symptoms in a severe case

of anorexia nervosa: A case report

D. Brigadeiro

1 ,

, C. Ferreira

2

, J. Magalhães

2

, J. Nunes

1

,

P. Santos

3

, E. Santos

2

, A. Pissarra

1

1

Hospital Sousa Martins - ULS - Guarda - EPE, Psiquiatria, Guarda,

Portugal

2

Centro Hospitalar Tondela - Viseu - EPE, Pediatria, Viseu, Portugal

3

Centro Hospitalar Tondela - Viseu - EPE, Pedopsiquiatria, Viseu,

Portugal

Corresponding author.

Introduction

The Wernicke-Korsakoff syndrome comprises a

complex of symptoms including Wernicke’s encephalopathy and

the Korsakoff’s syndrome. While the former is characterized by a

classic clinical triad of ataxia, ophtalmoplegia and a global confu-

sional state; the Korsakoff’s syndrome is characterized by memory

impairment and confabulation. These two entities are now consid-

ered as a clinical spectrum of a same disease caused by deficiency

of thiamine (vitamin B1).

Objective

To describe a case of Wernicke-Korsakoff Syndrome

with psychotic symptoms in a 13-year-old female patient with

anorexia nervosa.

Method

The patient and family were interviewed. Literature rel-

evant to the case was reviewed.

Results

A 13-year-old Caucasian female was admitted to the

emergency department with bradycardia (38 bpm) and a two-

month history of weight loss totaling 6 kg. This loss of weight was

a result of dietary restriction and over-exercise because she “felt

too fat”. On admission she has a body mass index of 12.17. She was

diagnosed with anorexia nervosa and was hospitalized. On day 11

after hospitalization, patient initiated alteration in behavior, fluctu-

atingmental state with periods of lucidity and periods of confusion,

memory impairment and psychotic symptoms, with paranoid delu-

sions and auditory hallucinations. The classic triad of Wernicke’s

encephalopathy was not present. The treatment with thiamine

was initiated and the symptoms including psychotic symptoms

improved.

Conclusion

Wernicke-Korsakoff syndrome should be considered

in cases of anorexia nervosa with a confusional state and memory

impairment even if the classic symptoms are not present.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1224

EV240

Disturbed sleep and activity as early

signs of ADHD in preschool children

A.K. Bundgaard

1 , 2 ,

, N. Bilenberg

3

, J. Asmussen

3

,

P. Munk Jørgensen

2

1

Psychiatric Hospital and University of Southern Denmark, Research

Unit - Child - and Adolescent Psychiatry - Region of Southern

Denmark, Odense C, Denmark