European Psychiatry - Volume 33 - March 2016

429 / 812

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S425
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV237
The evolution of cognitive functioning
in adolescents with early onset
psychosis
A. Bohus
Cluj-Napoca, Romania
Introduction Cognitive deficits (executive functions, verbal and
spatial learning and memory, visual processing and attention) are
a fundamental trait of schizophrenia.
Objective The main objective of this study is to compare the cog-
nitive functioning in psychotic adolescents at the psychosis onset
and after one year, using psychological tests.
Methods This is a longitudinal study, during a period of two
years and a half. Twenty-eight patients with first psychotic episode
agreed to participate to this study and were assessed during their
hospitalization in a university clinic for child and adolescent psychi-
atry in Cluj-Napoca, Romania. The diagnosis was based on DSM-IV
criteria. All the patients were initially assessed for intelligence level
using Raven Test and those withmental retardationwere excluded.
After one year, sixteen adolescents from the initial group were
reassessed. The cognitive functioning was assessed with Trail Mak-
ing A and B, verbal fluency tasks, Wisconsin Card Sorting Test and
Rey Auditory Verbal Learning Test. The results from patients group
were compared with those from healthy controls.
Results The results show weaker global cognitive performance
from adolescents with early onset psychosis, initially and at one-
year evaluation, than the healthy adolescents from the control
group.
Conclusions This results are consistent with those of previous
studies. The adolescents with early onset psychosis show multi-
ple cognitive impairments initially and one year after the psychosis
onset.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV238
Gender dysphoria in USMIJ of Toledo.
Report of a case
P. González Rivera , A. Hidalgo Borreguero ∗,
S. Bola˜no Mendoza , M. Soto Laguna , K. Preckler Pe˜na ,
F.J. Gonzalez Díaz , A. Zafra Villena , M. Perez Castellanos ,
J. Prados Gómez , P. Alvites Ahumada , R. Perez Asenjo ,
A.J. Benito Ruiz , A. Perez López , E. Landa Contreras ,
M. Fernandez-Torija Daza
1 Hospital Provincial de la Misericordia, Psiquiatria, Toledo, Spain
2 USMIJ, Psiquiatria, Toledo, Spain
3 Hospital 12 de Octubre, Psiquiatria, Madrid, Spain
4 Hospital Virgen del Prado, Psiquiatria, Talavera, Spain
5 Hospital Virgen de la Salud, Psiquiatria, Toledo, Spain
6 IVANE, Psiquiatria, Valencia, Spain
∗ Corresponding author.
The start of Child and Adolescent attention to gender dysphoria is
very recent. In our Unit, it has objectified a growing increase in such
demand over recent years.
As a typical example would be a patient of 13 years following
gender dysphoria begins to present school failure and behavior
problems at home with emotional instability.
According to the recommendations of the Group Identity and Sex-
ual Differentiation (GIDSEEN) after early detection is to guide
parents towards a comprehensive treatment at a specialized
interdisciplinary teams and a psychosocial approach to improve the
quality of life, decrease mental comorbidity and gender dysphoria
own. Having no such care in our community has been necessary to
make a referral to another community to attend this demand.
Currently it is giving adequate attention to these cases, but except
for referral to another community. However, as we are seeing pro-
gression care in our area in the future could be feasible. Therefore,
we consider as a first step dysphoria quantify each case in our area.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV239
Wernicke-Korsakoff syndrome with
psychotic symptoms in a severe case
of anorexia nervosa: A case report
D. Brigadeiro ∗, C. Ferreira , J. Magalhães , J. Nunes ,
P. Santos , E. Santos , A. Pissarra
1 Hospital Sousa Martins - ULS - Guarda - EPE, Psiquiatria, Guarda,
Portugal
2 Centro Hospitalar Tondela - Viseu - EPE, Pediatria, Viseu, Portugal
3 Centro Hospitalar Tondela - Viseu - EPE, Pedopsiquiatria, Viseu,
Portugal
∗ Corresponding author.
Introduction The Wernicke-Korsakoff syndrome comprises a
complex of symptoms including Wernicke’s encephalopathy and
the Korsakoff’s syndrome. While the former is characterized by a
classic clinical triad of ataxia, ophtalmoplegia and a global confu-
sional state; the Korsakoff’s syndrome is characterized by memory
impairment and confabulation. These two entities are now consid-
ered as a clinical spectrum of a same disease caused by deficiency
of thiamine (vitamin B1).
Objective To describe a case of Wernicke-Korsakoff Syndrome
with psychotic symptoms in a 13-year-old female patient with
anorexia nervosa.
Method The patient and family were interviewed. Literature rel-
evant to the case was reviewed.
Results A 13-year-old Caucasian female was admitted to the
emergency department with bradycardia (38 bpm) and a two-
month history of weight loss totaling 6 kg. This loss of weight was
a result of dietary restriction and over-exercise because she “felt
too fat”. On admission she has a body mass index of 12.17. She was
diagnosed with anorexia nervosa and was hospitalized. On day 11
after hospitalization, patient initiated alteration in behavior, fluctu-
atingmental state with periods of lucidity and periods of confusion,
memory impairment and psychotic symptoms, with paranoid delu-
sions and auditory hallucinations. The classic triad of Wernicke’s
encephalopathy was not present. The treatment with thiamine
was initiated and the symptoms including psychotic symptoms
improved.
Conclusion Wernicke-Korsakoff syndrome should be considered
in cases of anorexia nervosa with a confusional state and memory
impairment even if the classic symptoms are not present.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV240
Disturbed sleep and activity as early
signs of ADHD in preschool children
A.K. Bundgaard ∗, N. Bilenberg , J. Asmussen ,
P. Munk Jørgensen
1 Psychiatric Hospital and University of Southern Denmark, Research
Unit - Child - and Adolescent Psychiatry - Region of Southern
Denmark, Odense C, Denmark