European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S335
of patients treated with atomoxetine is characterized by different
comorbidities, anxious symptomatology and personality disorders.
Atomoxetine treatment with has also been shown its effectiveness
and safe despite the presence of concomitant comorbidities and
psychopharmacological treatment.
Conclusion Atomoxetine treatment with has been effective and
has proven good tolerability profile during treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW626
Effects of rTMS on cognitive and
negitive symptoms of schizophrenia:
A randomized double-blind
sham-controlled study
K. Zhuo ∗, Y. Wang , Z. Song , D. Liu
Shanghai Mental Health Center, Department of psychiatry, Shanghai,
China
∗ Corresponding author.
Background Investigators are urgently searching for options to
treat cognitive and negative symptoms in schizophrenia because
these symptoms are disabling and do not respond adequately
to antipsychotic or psychosocial treatment. This study evaluated
the efficacy of 20-Hz repetitive transcranial magnetic stimulation
(rTMS) applied to the left dorsolateral prefrontal cortex for the
treatment of cognitive and negative symptoms in schizophrenia.
Methods The study was a randomized double-blind sham-
controlled trial for 4 weeks. Seventy patients with schizophrenia
were randomly assigned into two treatment groups. After a 2-
week pretreatment phase, 34 patients were treated with 20-Hz
rTMS applied 5 days per week for 4 weeks to the left dorsolat-
eral prefrontal cortex (added to the ongoing treatment), and 33
patients were subjected to sham rTMS applied similarly. Nega-
tive symptoms were assessed with the Scale for the Assessment
of Negative Symptoms (SANS), the Positive and Negative symptom
scale (PANSS), and Cognitive symptoms were assessed by MATRICS
cognitive test battery (MCCB) Chinese version.
Results Sixty patients (33 individuals in active group and the
other 27 in the sham group) completed the treatment protocol. We
found that treatment with 20-Hz rTMS for 4 weeks significantly
improved negative symptoms in the active group as compared to
the sham group. However, There was no statistically significant dif-
ference in improvement in cognitive symptoms between the two
groups.
Conclusions These findings indicate that application of 20-Hz
rTMS to the left dorsolateral prefrontal cortex can effectively
improve the negative symptoms, while more optimized parame-
ters are needed to achieve improved therapeutic efficacy for the
treatment of cognitive symptoms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Women, Gender and Mental Health
EW627
The effects of vitamin B1 on
ameliorating of mental symptoms of
the premenstrual syndrome
S. Abdollahifard ∗, M. Maddahfar
1 Jahrom University of Medical Sciences, Nursing & Midwifery
Department, Jahrom, Iran
2 BHOWCO trading GmbH, BHOWCO trading GmbH, Frankfurt,
Germany
∗ Corresponding author.
Background & objective The premenstrual syndrome is a series of
physical, mental, and behavioral symptoms with various severities.
Different treatments have been introduced for the syndrome due to
its unknown complicated causes. Vitamin B1 (thiamin) may reduce
mental symptoms of the syndrome through affecting the perfor-
mance of coenzymes in the metabolism of carbohydrates and main
branch of amino acid that plays an important role in appearance of
mental symptoms of the PMS.
Methods In this double-blind placebo-controlled clinical trial, 80
students with PMS residing at dormitories of Jahrom University
were divided randomly into two groups, vitamin B1 and placebo.
The severity of the mental symptoms of PMS in two cycles, before
the intervention and during the intervention, was recorded by the
students. The data were collected using an information collection
form, PMS provisional diagnosis form, daily status record form,
Beck Depression Inventory. The data were analyzed using descrip-
tive and inferential statistics.
Results The comparison of vitamin B1 group before the inter-
vention with that after the intervention showed that vitamin B1
reducedmeanmental symptoms (35.08%) significantly (P < 0.0001).
Moreover, there was a significant difference between vitamin B1
and placebo groups in terms of mean mental symptoms, as mean
symptoms in vitamin B1 group was significantly lower than that in
the placebo group (P < 0.0001).
Conclusion It seems that vitamin B1 is effective in recovery of
mental symptoms of PMS. Therefore, this vitamin can be used to
reach a major goal of midwifery, that is, reduction of mental symp-
tom severity of PMS, without any side effects.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW628
Exploratory randomized controlled
trial of a group psychological
intervention for postnatal depression
in British mothers of South Asian
origin
N. Husain ∗, K. Lovell , F. lunat , N. Atif , A. Bhokari ,
I. Bhojani , B. Tomenson , W. Waheed , A. Rahman ,
N. Chaudhry
1 University of Manchester, Institute of brain-behaviour and mental
health, Manchester, United Kingdom
2 University of Manchester, School of nursing- midwifery and social
work, Manchester, United Kingdom
3 Lancashire Care NHS Foundation Trust, Research and Innovation,
Preston, United Kingdom
4 Cheetamhill medical practice, General Practice, Manchester, United
Kingdom
5 NHS Blackburn with Darwen CCG, Shifa surgery, Blackburn, United
Kingdom
6 University of Manchester, Academic Health Sciences Centre,
Manchester, United Kingdom
7 University of Liverpool, Institute of Psychology- Health & Society,
Liverpool, United Kingdom
∗ Corresponding author.
Introduction The rates of postnatal depression (PND) in British
South Asian (BSA) women are higher than the general population.
PND is known to cause disability and suffering in women and nega-
tive consequences for their infants and their family with huge costs