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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S335

of patients treated with atomoxetine is characterized by different

comorbidities, anxious symptomatology and personality disorders.

Atomoxetine treatment with has also been shown its effectiveness

and safe despite the presence of concomitant comorbidities and

psychopharmacological treatment.

Conclusion

Atomoxetine treatment with has been effective and

has proven good tolerability profile during treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.743

EW626

Effects of rTMS on cognitive and

negitive symptoms of schizophrenia:

A randomized double-blind

sham-controlled study

K. Zhuo

, Y. Wang , Z. Song , D. Liu

Shanghai Mental Health Center, Department of psychiatry, Shanghai,

China

Corresponding author.

Background

Investigators are urgently searching for options to

treat cognitive and negative symptoms in schizophrenia because

these symptoms are disabling and do not respond adequately

to antipsychotic or psychosocial treatment. This study evaluated

the efficacy of 20-Hz repetitive transcranial magnetic stimulation

(rTMS) applied to the left dorsolateral prefrontal cortex for the

treatment of cognitive and negative symptoms in schizophrenia.

Methods

The study was a randomized double-blind sham-

controlled trial for 4 weeks. Seventy patients with schizophrenia

were randomly assigned into two treatment groups. After a 2-

week pretreatment phase, 34 patients were treated with 20-Hz

rTMS applied 5 days per week for 4 weeks to the left dorsolat-

eral prefrontal cortex (added to the ongoing treatment), and 33

patients were subjected to sham rTMS applied similarly. Nega-

tive symptoms were assessed with the Scale for the Assessment

of Negative Symptoms (SANS), the Positive and Negative symptom

scale (PANSS), and Cognitive symptoms were assessed by MATRICS

cognitive test battery (MCCB) Chinese version.

Results

Sixty patients (33 individuals in active group and the

other 27 in the sham group) completed the treatment protocol. We

found that treatment with 20-Hz rTMS for 4 weeks significantly

improved negative symptoms in the active group as compared to

the sham group. However, There was no statistically significant dif-

ference in improvement in cognitive symptoms between the two

groups.

Conclusions

These findings indicate that application of 20-Hz

rTMS to the left dorsolateral prefrontal cortex can effectively

improve the negative symptoms, while more optimized parame-

ters are needed to achieve improved therapeutic efficacy for the

treatment of cognitive symptoms.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.744

Women, Gender and Mental Health

EW627

The effects of vitamin B1 on

ameliorating of mental symptoms of

the premenstrual syndrome

S. Abdollahifard

1 ,

, M. Maddahfar

2

1

Jahrom University of Medical Sciences, Nursing & Midwifery

Department, Jahrom, Iran

2

BHOWCO trading GmbH, BHOWCO trading GmbH, Frankfurt,

Germany

Corresponding author.

Background & objective

The premenstrual syndrome is a series of

physical, mental, and behavioral symptoms with various severities.

Different treatments have been introduced for the syndrome due to

its unknown complicated causes. Vitamin B1 (thiamin) may reduce

mental symptoms of the syndrome through affecting the perfor-

mance of coenzymes in the metabolism of carbohydrates and main

branch of amino acid that plays an important role in appearance of

mental symptoms of the PMS.

Methods

In this double-blind placebo-controlled clinical trial, 80

students with PMS residing at dormitories of Jahrom University

were divided randomly into two groups, vitamin B1 and placebo.

The severity of the mental symptoms of PMS in two cycles, before

the intervention and during the intervention, was recorded by the

students. The data were collected using an information collection

form, PMS provisional diagnosis form, daily status record form,

Beck Depression Inventory. The data were analyzed using descrip-

tive and inferential statistics.

Results

The comparison of vitamin B1 group before the inter-

vention with that after the intervention showed that vitamin B1

reducedmeanmental symptoms (35.08%) significantly (

P

< 0.0001).

Moreover, there was a significant difference between vitamin B1

and placebo groups in terms of mean mental symptoms, as mean

symptoms in vitamin B1 group was significantly lower than that in

the placebo group (

P

< 0.0001).

Conclusion

It seems that vitamin B1 is effective in recovery of

mental symptoms of PMS. Therefore, this vitamin can be used to

reach a major goal of midwifery, that is, reduction of mental symp-

tom severity of PMS, without any side effects.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.745

EW628

Exploratory randomized controlled

trial of a group psychological

intervention for postnatal depression

in British mothers of South Asian

origin

N. Husain

1 ,

, K. Lovell

2

, F. lunat

3

, N. Atif

1

, A. Bhokari

4

,

I. Bhojani

5

, B. Tomenson

1

, W. Waheed

6

, A. Rahman

7

,

N. Chaudhry

1

1

University of Manchester, Institute of brain-behaviour and mental

health, Manchester, United Kingdom

2

University of Manchester, School of nursing- midwifery and social

work, Manchester, United Kingdom

3

Lancashire Care NHS Foundation Trust, Research and Innovation,

Preston, United Kingdom

4

Cheetamhill medical practice, General Practice, Manchester, United

Kingdom

5

NHS Blackburn with Darwen CCG, Shifa surgery, Blackburn, United

Kingdom

6

University of Manchester, Academic Health Sciences Centre,

Manchester, United Kingdom

7

University of Liverpool, Institute of Psychology- Health & Society,

Liverpool, United Kingdom

Corresponding author.

Introduction

The rates of postnatal depression (PND) in British

South Asian (BSA) women are higher than the general population.

PND is known to cause disability and suffering in women and nega-

tive consequences for their infants and their family with huge costs