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Page Background

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S18–S55

S19

Methods

A graph theoretical approach was used to analyse the

connectivity in networks centered on:

– Broca’s area;

– Wernicke’s area.

Connectivity information was acquired using diffusion tensor

imaging (DTI).

Results

Compared to healthy controls, adolescents with

schizophrenia displayed a lower average degree of connectiv-

ity with the left inferior frontal gyrus (Broca’s area). No significant

differences were found in the degree of connectivity with the right

inferior frontal gyrus and the superior temporal gyrus bilaterally

(Wernicke’s area).

Conclusions

The results suggest a link between schizophrenia

and impairment to areas where CDs associated with inner speech

plausibly originate.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.818

S03

GRIN2B mediates susceptibility to

affective problems in children and

adolescents

M. Nobile

Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio

Medea, Bosisio Parini, Lecco, Italy

Objectives

Association studies have implicated the N-methyl-

D-aspartate receptor 2B subunit gene (

GRIN2B

) as candidate

for different brain illnesses, also including both internalizing

and externalizing disorders. Here, we explored the association

between selected SNPs of GRIN2B (rs5796555-/A; rs1012586C/G;

rs2268119A/T; rs2216128A/G; rs11609779C/T; rs2192973G/A)

and attention problems in children an adolescents as assessed by

CBCL 6/18 (Achenbach and Rescorla, 2001).

Methods

In a large cohort of 320 Italian nuclear families selected

from an ongoing comprehensive project on child and adolescent

psychopathology performed at two sites of our Institutes (BP and

UD), we performed a family-based association study to determine

whether the

GRIN2B

gene influence and/or mediates susceptibility

to attention problems through time. Genetic associationwas inves-

tigated by the quantitative transmission disequilibrium test (QTDT,

version 2.5.1; Abecasis et al., 2000). Quantitative traits were ana-

lyzed using the ‘-wega’ and the ‘-ao’ options. Empirical

P

-values

were computed from 10,000 Monte-Carlo permutations, and the

significance levelswere adjusted by the false discovery ratemethod

(Storey, 2002) applied to the tests performed for each marker (i.e.,

8 phenotypes) at two different point times. Latent profile analysis

was performed to assess the effect of gene on different trajecto-

ries over time. The effect of environmental determinants was also

evaluated.

Results

Evidence for significant association of GRIN2B-

rs5796555-/A was found with attention problems both at first and

second evaluation. Latent profile analysis suggested significant

association with specific trajectories and specific environmental

factors.

Conclusions

These results provide preliminary evidence of an

association between the GRIN2B polymorphism and continuity of

attention problems throughout adolescence within an Italian pop-

ulation of referred children and adolescents, suggesting that the

GRIN2B

genes could play a role in susceptibility to attention prob-

lems during developmental age.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.819

Biological markers of short-term and long-term

treatment outcome in mental disorders

S04

Brain glutamate levels and

antipsychotic response in

schizophrenia

A. Egerton

Department of Psychosis Studies, Institute of Psychiatry, Psychology

and Neuroscience, King’s College London, London, United Kingdom

There is considerable interest in identifying biomarkers of antipsy-

chotic response in schizophrenia. Glutamate is one key candidate.

The development of brain imaging techniques for measuring brain

glutamate levels has allowed this hypothesis to be tested directly

in patients. This talk will present our ongoing research examining

the relationship between brain glutamate levels and antipsychotic

response in first-episode psychosis and in treatment-resistant

schizophrenia. I will summarise our results from both our com-

pleted and ongoing studies, to consider whether glutamate imaging

might be useful in the future to identify patients who would ben-

efit from non-dopaminergic antipsychotic drugs and inform novel,

glutamate-based, treatment strategies.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.820

S05

Biochemical and genetic markers in

patients with alcohol dependence and

affective disorders and their

correlation with alcohol intake

U. Preus

s 1 ,

, F . W

urst

2

1

Martin-Luther University, Halle-Wittenberg, Department of

Psychiatry, Psychotherapy and Psychosomatics, Germany

2

Paracelsus University Salzburg, Psychiatry, Salzburg, Austria

Corresponding author.

Rates of comorbid affective disorders in alcohol-dependent indi-

viduals are significant. Biomarkers of alcohol use may support the

diagnosis of high and frequent alcohol use in these individuals. The

aim of these analyses of the WHO-ISBRA Study on State and Trait

Markers of Alcohol Use and Dependence is to compare biomark-

ers of alcohol use across individuals with and without comorbid

alcohol dependence and affective disorders. Significantly, higher

values of these biomarkers are hypothesized in individuals with

comorbid disorders compared to alcohol dependence only. Assess-

ment of Alcohol dependence and comorbid depression and bipolar

disorders were conducted using an adapted version of the Alco-

hol Use Disorder and Associated Disabilities Interview Schedule

(AUDADIS). Altogether,

n

= 1863 individuals were included into

the analyses, of whom

n

= 299 had a lifetime history of depres-

sion and

n

= 20 a bipolar disorder. Clinical characteristics like mean

alcohol intake last month and biomarkers including ASAT, GGT,

CDT, 5-HTOL/5-HIAA ratio and MAO-Activity were included into

the analyses. Results indicate that AD only subjects had higher

measures of all biomarkers compared to comorbid bipolar and

depression subjects, while the latter had a higher alcohol intake

during last month.

Since this is a cross-sectional study, conducted in emergency rooms

of several countries, this allegedly divergent result in alcohol intake

in comorbid subjects compared to higher biomarkers in AD only

subjects may indicate that drinking is more frequent in alcohol-

dependent individuals while bipolar and depressed subjects may

have more episodic pattern of alcohol intake. The latter may lead

to shorter periods of intake compared to the chronic and frequent