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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S143

Corresponding author.

Introduction

Studies on relationships between music, visual

imagery or therapeutic techniques, like mindfulness and emo-

tions have been undertaken with varying success in predominantly

adult populations. Their role in the child and adolescent population

remains unclear.

Aims and objectives

We undertook a systematic literature review

to assess current evidence in the use of music, guided imagery

with/without therapeutic techniques for emotional processing in

adults, children and adolescents.

Methods

We identified 87 relevant papers (JSTOR, OVIDMedline,

Cochrane, PubMed, Science Direct, Taylor & Francis andWiley). We

excluded non-English papers and qualitative analyses. Nine studies

used quantitative techniques (Neuroimaging) for assessing emo-

tional change using musical and non-musical stimuli (

n

= 77). Of

these, four studies used fMRI and two used PET scans.

Results

fMRI demonstrates a significant relation between amyg-

dalar activation and emotional response to visual imagery (

P

< 0.05,

n

= 45). Early information using PET scanning shows a significant

association between activation of different parts of brain with var-

ied visual imagery (one study,

n

= 5) and varied music (one study,

n

= 10). There is similarity in the activation of specific cortical areas

using musical and non-musical stimuli. Two separate studies of

patients with damaged amygdala due to disease (

n

= 6) showed

significant impairment of emotional processing and response.

Conclusions

There is early encouraging data providing evidence

of possible relationships betweenmusic and visual imagery in emo-

tional processing. Further studies are needed to examine these

in detail, especially in children/adolescents. Music with visual

imagery may be a useful adjunct in the self-guided processing of

milder emotional disorders with components of anxiety, depres-

sion, adjustment and emotional dysregulation.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.197

EW80

Time-course of treatment-emergent

adverse events in a long-term safety

study of lisdexamfetamine dimesylate

in children and adolescents with

ADHD

I. Hernández Otero

1 ,

, T. Banaschewski

2

, P. Nagy

3

,

C.A. Soutullo

4

, A. Zuddas

5

, B. Caballero

6

, B. Geibel

7

, B. Yan

8

,

D.R. Coghill

9

1

University Hospital Virgen de la Victoria–Maritime Hospital, Unit of

Child and Adolescent Mental Health USMIJ, Torremolinos, Spain

2

Central Institute of Mental Health, Medical Faculty Mannheim,

University of Heidelberg, Department of Child and Adolescent

Psychiatry and Psychotherapy, Mannheim, Germany

3

Vadaskert Child and Adolescent Psychiatry Hospital and Outpatient

Clinic, Child and Adolescent Psychiatry, Budapest, Hungary

4

University of Navarra Clinic, Child and Adolescent Psychiatry Unit,

Department of Psychiatry and Medical Psychology, Pamplona, Spain

5

University of Cagliari, Department of Biomedical Sciences, Section of

Neuroscience and Clinical Pharmacology, Cagliari, Italy

6

Shire, Neuroscience, Zug, Switzerland

7

Shire, Neuroscience, Wayne, USA

8

Shire, Biostatistics, Wayne, USA

9

University of Dundee, Division of Neuroscience, Dundee, United

Kingdom

Corresponding author.

Introduction

The long-term safety and efficacy of lisdexamfe-

tamine dimesylate (LDX) in children and adolescentswith attention

deficit/hyperactivity disorder (ADHD) was evaluated in a European

2-year, open-label study (SPD489-404).

Objective

To evaluate the time-course of treatment-emergent

adverse events (TEAEs) in SPD489-404.

Methods

Participants aged 6–17 years received open-label LDX

(30, 50 or 70mg/day) for 104 weeks (4 weeks dose-optimization;

100 weeks dose-maintenance).

Results

All enrolled participants (

n

= 314) were included in the

safety population and 191 (60.8%) completed the study. TEAEs

occurred in 282 (89.8%) participants; most were mild or mod-

erate. TEAEs considered by the investigators as related to LDX

were reported by 232 (73.9%) participants with the following

reported for

10% of participants: decreased appetite (49.4%),

weight decreased (18.2%), insomnia (13.1%). TEAEs leading to dis-

continuation and serious TEAEs occurred in 39 (12.4%) and 28 (8.9%)

participants, respectively. The median (range) time to first onset

and duration, respectively, of TEAEs identified by the sponsor as

being of special interest were: insomnia (insomnia, initial insom-

nia, middle insomnia, terminal insomnia), 17.0 (1–729) and 42.8

(1–739) days; weight decreased, 29.0 (1–677) and 225.0 (26–724)

days; decreased appetite, 13.5 (1–653) and 169.0 (1–749) days;

headache, 22.0 (1–718) and 2.0 (1–729) days. Reports of insomnia,

weight decreased, decreased appetite and headache were highest

in the first 4–12 weeks.

Conclusions

TEAEs associated with long-term LDX treatment

were characteristic of stimulant medications, with the greatest

incidence observed during the first 4–12 weeks.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.198

EW81

Integrative approach to the

construction of psychosocial

rehabilitation of mental and

behaviour disorders in children

moved out of “Anti-Terrorist

Operation” zone

B. Mykhaylov

1 ,

, M .

Vodka

2 , T. A

liieva

1 , I. V

ashkite

1

1

Kharkov Medical Academy of Postgraduate Education, Kharkov,

Psychotherapy, Kharkov, Ukraine

2

The International Charity Fund “Alexander Feldman Fund”, Director,

Kharkov, Ukraine

Corresponding author.

Introduction

The problem of children’s mental health in Ukraine

– it is one of the most pressing problems in the country’s health.

This is due to the increasing number of extreme situations (military

operations in the territory of Ukraine) for the last time that calls

for the training of specialists capable of carrying out psychosocial

rehabilitation to victims of “anti-terrorist operation”(ATO).

Objectives

The mental and behaviour disorders in children

affected of ATO. We studied 261 families: 107 adults and 154

children. The aim of the project was to optimize the provision

of psycho-social support for children and adolescents with prob-

lems of the psychic sphere by developing a system of psychological

adjustment and social education at the Centre for psychosocial

rehabilitation of children, as well as the creation of the necessary

conditions that expand the comfort and a safe space for the child

to enhance positive impacts and mitigate negative impacts of the

social environment.

Methods

The leading role was played by a combination of

two areas of work, namely the psychocorrection (trainings, art-,

individual-, family-, hyppo-therapy) and social work.

Results

In 85.4% of the children showed stabilization of mental

and emotional state, reducing aggression, increasing motivation to

social activity. In 56.3% of families – reducing conflict relations.

Conclusions

The non-standardway of psycho-correction allowed

organizing a fruitful and creative leisure, which resulted in the