

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
S143
∗
Corresponding author.
Introduction
Studies on relationships between music, visual
imagery or therapeutic techniques, like mindfulness and emo-
tions have been undertaken with varying success in predominantly
adult populations. Their role in the child and adolescent population
remains unclear.
Aims and objectives
We undertook a systematic literature review
to assess current evidence in the use of music, guided imagery
with/without therapeutic techniques for emotional processing in
adults, children and adolescents.
Methods
We identified 87 relevant papers (JSTOR, OVIDMedline,
Cochrane, PubMed, Science Direct, Taylor & Francis andWiley). We
excluded non-English papers and qualitative analyses. Nine studies
used quantitative techniques (Neuroimaging) for assessing emo-
tional change using musical and non-musical stimuli (
n
= 77). Of
these, four studies used fMRI and two used PET scans.
Results
fMRI demonstrates a significant relation between amyg-
dalar activation and emotional response to visual imagery (
P
< 0.05,
n
= 45). Early information using PET scanning shows a significant
association between activation of different parts of brain with var-
ied visual imagery (one study,
n
= 5) and varied music (one study,
n
= 10). There is similarity in the activation of specific cortical areas
using musical and non-musical stimuli. Two separate studies of
patients with damaged amygdala due to disease (
n
= 6) showed
significant impairment of emotional processing and response.
Conclusions
There is early encouraging data providing evidence
of possible relationships betweenmusic and visual imagery in emo-
tional processing. Further studies are needed to examine these
in detail, especially in children/adolescents. Music with visual
imagery may be a useful adjunct in the self-guided processing of
milder emotional disorders with components of anxiety, depres-
sion, adjustment and emotional dysregulation.
Disclosure of interest
The authors have not supplied their decla-
ration of competing interest.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.197EW80
Time-course of treatment-emergent
adverse events in a long-term safety
study of lisdexamfetamine dimesylate
in children and adolescents with
ADHD
I. Hernández Otero
1 ,∗
, T. Banaschewski
2, P. Nagy
3,
C.A. Soutullo
4, A. Zuddas
5, B. Caballero
6, B. Geibel
7, B. Yan
8,
D.R. Coghill
91
University Hospital Virgen de la Victoria–Maritime Hospital, Unit of
Child and Adolescent Mental Health USMIJ, Torremolinos, Spain
2
Central Institute of Mental Health, Medical Faculty Mannheim,
University of Heidelberg, Department of Child and Adolescent
Psychiatry and Psychotherapy, Mannheim, Germany
3
Vadaskert Child and Adolescent Psychiatry Hospital and Outpatient
Clinic, Child and Adolescent Psychiatry, Budapest, Hungary
4
University of Navarra Clinic, Child and Adolescent Psychiatry Unit,
Department of Psychiatry and Medical Psychology, Pamplona, Spain
5
University of Cagliari, Department of Biomedical Sciences, Section of
Neuroscience and Clinical Pharmacology, Cagliari, Italy
6
Shire, Neuroscience, Zug, Switzerland
7
Shire, Neuroscience, Wayne, USA
8
Shire, Biostatistics, Wayne, USA
9
University of Dundee, Division of Neuroscience, Dundee, United
Kingdom
∗
Corresponding author.
Introduction
The long-term safety and efficacy of lisdexamfe-
tamine dimesylate (LDX) in children and adolescentswith attention
deficit/hyperactivity disorder (ADHD) was evaluated in a European
2-year, open-label study (SPD489-404).
Objective
To evaluate the time-course of treatment-emergent
adverse events (TEAEs) in SPD489-404.
Methods
Participants aged 6–17 years received open-label LDX
(30, 50 or 70mg/day) for 104 weeks (4 weeks dose-optimization;
100 weeks dose-maintenance).
Results
All enrolled participants (
n
= 314) were included in the
safety population and 191 (60.8%) completed the study. TEAEs
occurred in 282 (89.8%) participants; most were mild or mod-
erate. TEAEs considered by the investigators as related to LDX
were reported by 232 (73.9%) participants with the following
reported for
≥
10% of participants: decreased appetite (49.4%),
weight decreased (18.2%), insomnia (13.1%). TEAEs leading to dis-
continuation and serious TEAEs occurred in 39 (12.4%) and 28 (8.9%)
participants, respectively. The median (range) time to first onset
and duration, respectively, of TEAEs identified by the sponsor as
being of special interest were: insomnia (insomnia, initial insom-
nia, middle insomnia, terminal insomnia), 17.0 (1–729) and 42.8
(1–739) days; weight decreased, 29.0 (1–677) and 225.0 (26–724)
days; decreased appetite, 13.5 (1–653) and 169.0 (1–749) days;
headache, 22.0 (1–718) and 2.0 (1–729) days. Reports of insomnia,
weight decreased, decreased appetite and headache were highest
in the first 4–12 weeks.
Conclusions
TEAEs associated with long-term LDX treatment
were characteristic of stimulant medications, with the greatest
incidence observed during the first 4–12 weeks.
Disclosure of interest
The authors have not supplied their decla-
ration of competing interest.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.198EW81
Integrative approach to the
construction of psychosocial
rehabilitation of mental and
behaviour disorders in children
moved out of “Anti-Terrorist
Operation” zone
B. Mykhaylov
1 ,∗
, M .Vodka
2 , T. Aliieva
1 , I. Vashkite
11
Kharkov Medical Academy of Postgraduate Education, Kharkov,
Psychotherapy, Kharkov, Ukraine
2
The International Charity Fund “Alexander Feldman Fund”, Director,
Kharkov, Ukraine
∗
Corresponding author.
Introduction
The problem of children’s mental health in Ukraine
– it is one of the most pressing problems in the country’s health.
This is due to the increasing number of extreme situations (military
operations in the territory of Ukraine) for the last time that calls
for the training of specialists capable of carrying out psychosocial
rehabilitation to victims of “anti-terrorist operation”(ATO).
Objectives
The mental and behaviour disorders in children
affected of ATO. We studied 261 families: 107 adults and 154
children. The aim of the project was to optimize the provision
of psycho-social support for children and adolescents with prob-
lems of the psychic sphere by developing a system of psychological
adjustment and social education at the Centre for psychosocial
rehabilitation of children, as well as the creation of the necessary
conditions that expand the comfort and a safe space for the child
to enhance positive impacts and mitigate negative impacts of the
social environment.
Methods
The leading role was played by a combination of
two areas of work, namely the psychocorrection (trainings, art-,
individual-, family-, hyppo-therapy) and social work.
Results
In 85.4% of the children showed stabilization of mental
and emotional state, reducing aggression, increasing motivation to
social activity. In 56.3% of families – reducing conflict relations.
Conclusions
The non-standardway of psycho-correction allowed
organizing a fruitful and creative leisure, which resulted in the